Understanding Health Benefits of Xanthones
A question that is asked a lot is what are Xanthones Health Benefits? Research reveals that xanthones from the mangosteen fruit hulls exhibits antibacterial, antifungal, and anti-inflammatory properties in the laboratory-in cell cultures and animal studies. To date, there are no published studies describing the research involving human subjects.
Investigators in Thailand found that xanthones isolated from the fruit hulls and the edible arils and seeds of mangos teen had powerful antituberculosis actions. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effects against Mycobacterium tuberculosis, the bacteria that causes tuberculosis. Researchers in India reported that several xanthones isolated from the fruit hulls of mangos teen demonstrated good inhibitory action against three fungi-Fugarium oxysporum vasinfectum, Alternaria tennuis, and Dreschlera oryzae.
Investigators in Japan found that alpha-mangostin isolated from the stem bark of Garcinia mangostana L, was effective against antibiotic-resistant strains of bacteria-against vancomycin-resistant Enterococci (gram-positive cocci that cause urinary tract infections, bacteremia, bacterial endocarditis, diverticulitis, and meningitis) and methicillin-resistant Staphylocossus aureus, a gram-positive cocci that can cause illnesses ranging from minor skin infections to life-threatening diseases such as pneumonia, meningitis, endocarditis, toxic shock syndrome, and septicaemia (a disease caused by the spread of bacteria and their toxins in the bloodstream). The investigators also observed partial synergism-the capacity to work better than separately-between alpha-mangostin and commercially available prescription antibiotics such as ampicillin and minocycline. Theyopined that their findings suggested that alpha-mangostin alone or in combination with antibiotics might be useful in controlling infections.
In Thailand, many plant species have been widely used to cure infections. In 2005, researchers tested nine medicinal plant extracts to assess their activity against methicillin-resistant Staphylococcus aureus. They found that mangos teen extract possessed significant activity against the bacteria and attributed this activity to the presence of metabolic toxins or broad-spectrum antibacterial compounds. They felt that the antibacterial action observed might in part be caused by the high levels of tannin in the extract, which is known to exert antimicrobial effects.
There is considerable evidence that xanthones act to reduce the synthesis of prostaglandins-potent hormone-like substances that participate in a wide range of body functions, such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, the control of blood pressure, and the modulation of inflammation. Xanthones also prevent oxidative damage by functioning as free radical scavengers, act as histamine and serotonin-receptor blockers, and also inhibit HIV-1 protease, which means they serve to inhibit viral production and reduce viral spread.
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